BDBM106857 US8592455, 57

SMILES: C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1ccccc1F

InChI Key: InChIKey=ATNCLUHEGCYVPT-XHSDSOJGSA-N

Data: 3 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 106857   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM106857 (US8592455, 57) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1ccccc1F |r| Show InChI InChI=1S/C24H24F2N4O/c1-14-10-15(12-16(27)11-14)17-8-9-28-13-22(17)30-24(31)21-7-6-20(26)23(29-21)18-4-2-3-5-19(18)25/h2-9,13-16H,10-12,27H2,1H3,(H,30,31)/t14-,15+,16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of PIM1 kinase (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by kinase-Glo assay				J Med Chem 58: 8373-86 (2015) Article DOI: 10.1021/acs.jmedchem.5b01275 BindingDB Entry DOI: 10.7270/Q2H41VGN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM106857 (US8592455, 57) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1ccccc1F |r| Show InChI InChI=1S/C24H24F2N4O/c1-14-10-15(12-16(27)11-14)17-8-9-28-13-22(17)30-24(31)21-7-6-20(26)23(29-21)18-4-2-3-5-19(18)25/h2-9,13-16H,10-12,27H2,1H3,(H,30,31)/t14-,15+,16-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	<3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of PIM3 kinase (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by kinase-Glo assay				J Med Chem 58: 8373-86 (2015) Article DOI: 10.1021/acs.jmedchem.5b01275 BindingDB Entry DOI: 10.7270/Q2H41VGN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM106857 (US8592455, 57) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1ccccc1F |r| Show InChI InChI=1S/C24H24F2N4O/c1-14-10-15(12-16(27)11-14)17-8-9-28-13-22(17)30-24(31)21-7-6-20(26)23(29-21)18-4-2-3-5-19(18)25/h2-9,13-16H,10-12,27H2,1H3,(H,30,31)/t14-,15+,16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of PIM2 kinase (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by kinase-Glo assay				J Med Chem 58: 8373-86 (2015) Article DOI: 10.1021/acs.jmedchem.5b01275 BindingDB Entry DOI: 10.7270/Q2H41VGN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM106857 (US8592455, 57) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1ccccc1F |r| Show InChI InChI=1S/C24H24F2N4O/c1-14-10-15(12-16(27)11-14)17-8-9-28-13-22(17)30-24(31)21-7-6-20(26)23(29-21)18-4-2-3-5-19(18)25/h2-9,13-16H,10-12,27H2,1H3,(H,30,31)/t14-,15+,16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
Novartis AG US Patent					Assay Description The activity of PIM1, PIM2, and PIM3 is measured using a luciferase-luciferin based ATP detection reagent to quantify ATP depletion resulting from ki...				US Patent US8592455 (2013) BindingDB Entry DOI: 10.7270/Q2FF3R0C
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM106857 (US8592455, 57) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1ccccc1F |r| Show InChI InChI=1S/C24H24F2N4O/c1-14-10-15(12-16(27)11-14)17-8-9-28-13-22(17)30-24(31)21-7-6-20(26)23(29-21)18-4-2-3-5-19(18)25/h2-9,13-16H,10-12,27H2,1H3,(H,30,31)/t14-,15+,16-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	n/a
Novartis AG US Patent					Assay Description The activity of PIM1, PIM2, and PIM3 is measured using a luciferase-luciferin based ATP detection reagent to quantify ATP depletion resulting from ki...				US Patent US8592455 (2013) BindingDB Entry DOI: 10.7270/Q2FF3R0C
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM106857 (US8592455, 57) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1ccccc1F |r| Show InChI InChI=1S/C24H24F2N4O/c1-14-10-15(12-16(27)11-14)17-8-9-28-13-22(17)30-24(31)21-7-6-20(26)23(29-21)18-4-2-3-5-19(18)25/h2-9,13-16H,10-12,27H2,1H3,(H,30,31)/t14-,15+,16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	n/a
Novartis AG US Patent					Assay Description The activity of PIM1, PIM2, and PIM3 is measured using a luciferase-luciferin based ATP detection reagent to quantify ATP depletion resulting from ki...				US Patent US8592455 (2013) BindingDB Entry DOI: 10.7270/Q2FF3R0C
					More data for this Ligand-Target Pair