BDBM107654 US8575157, 28

SMILES: CC(C)[C@]1(CCCO)CCN([C@@H](C)c2ccc(cc2)-c2ccn(C)c(=O)c2)C(=O)O1

InChI Key: InChIKey=BLIKXDAKWNGQNT-UUOWRZLLSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 107654   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM107654 (US8575157, 28) Show SMILES CC(C)[C@]1(CCCO)CCN([C@@H](C)c2ccc(cc2)-c2ccn(C)c(=O)c2)C(=O)O1 |r| Show InChI InChI=1S/C24H32N2O4/c1-17(2)24(11-5-15-27)12-14-26(23(29)30-24)18(3)19-6-8-20(9-7-19)21-10-13-25(4)22(28)16-21/h6-10,13,16-18,27H,5,11-12,14-15H2,1-4H3/t18-,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.89	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH US Patent					Assay Description The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...				US Patent US8575157 (2013) BindingDB Entry DOI: 10.7270/Q2416VPS
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM107654 (US8575157, 28) Show SMILES CC(C)[C@]1(CCCO)CCN([C@@H](C)c2ccc(cc2)-c2ccn(C)c(=O)c2)C(=O)O1 |r| Show InChI InChI=1S/C24H32N2O4/c1-17(2)24(11-5-15-27)12-14-26(23(29)30-24)18(3)19-6-8-20(9-7-19)21-10-13-25(4)22(28)16-21/h6-10,13,16-18,27H,5,11-12,14-15H2,1-4H3/t18-,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH US Patent					Assay Description The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...				US Patent US8575157 (2013) BindingDB Entry DOI: 10.7270/Q2416VPS
					More data for this Ligand-Target Pair