BDBM107696 US8598210, Table XV, 2::US8722895, 2: {[5-(4-Chloro-phenyl)-3-hydroxy-pyridine- 2-carbonyl]-amino}-acetic acid methyl ester::US9598370, Example 00127::USRE47437, Example {[5-(4-Chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid methyl ester
SMILES: COC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(Cl)cc1
InChI Key: InChIKey=BYGKIXAXITXFDW-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107696 (US8598210, Table XV, 2 | US8722895, 2: {[5-(4-Chlo...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Akebia Therapeutics, Inc. US Patent | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | US Patent US8598210 (2013) BindingDB Entry DOI: 10.7270/Q2M04428 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor A (Homo sapiens (Human)) | BDBM107696 (US8598210, Table XV, 2 | US8722895, 2: {[5-(4-Chlo...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Akebia Therapeutics, Inc. US Patent | Assay Description HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight... | US Patent US8598210 (2013) BindingDB Entry DOI: 10.7270/Q2M04428 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107696 (US8598210, Table XV, 2 | US8722895, 2: {[5-(4-Chlo...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Akebia Therapeutics, Inc. US Patent | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | US Patent US8722895 (2014) BindingDB Entry DOI: 10.7270/Q25Q4TRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor A (Homo sapiens (Human)) | BDBM107696 (US8598210, Table XV, 2 | US8722895, 2: {[5-(4-Chlo...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
University of California at Los Angeles | Assay Description HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight... | Bioorg Med Chem 17: 7174-85 (2009) BindingDB Entry DOI: 10.7270/Q2D50Q9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor A (Homo sapiens (Human)) | BDBM107696 (US8598210, Table XV, 2 | US8722895, 2: {[5-(4-Chlo...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Akebia Therapeutics, Inc. US Patent | US Patent US9598370 (2017) BindingDB Entry DOI: 10.7270/Q20G3N64 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107696 (US8598210, Table XV, 2 | US8722895, 2: {[5-(4-Chlo...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California at Los Angeles | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | Bioorg Med Chem 17: 7174-85 (2009) BindingDB Entry DOI: 10.7270/Q2D50Q9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107696 (US8598210, Table XV, 2 | US8722895, 2: {[5-(4-Chlo...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Akebia Therapeutics, Inc. US Patent | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | US Patent US9598370 (2017) BindingDB Entry DOI: 10.7270/Q20G3N64 | |||||||||||
More data for this Ligand-Target Pair |