BDBM107701 US8598210, Table XV, 7::US8722895, 7: {[5-(2-Chloro-phenyl)-3-hydroxy-pyridine- 2-carbonyl]-amino}-acetic acid methyl ester::US9598370, Example 00132::USRE47437, Example {[5-(2-Chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid methyl ester

SMILES: COC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl

InChI Key: InChIKey=BYSUDLAKLIQTEQ-UHFFFAOYSA-N

Data: 8 IC50  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 107701   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Egl nine homolog 1 (Homo sapiens (Human))	BDBM107701 (US8598210, Table XV, 7 | US8722895, 7: {[5-(2-Chlo...) Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-9(7-17-14)10-4-2-3-5-11(10)16/h2-7,19H,8H2,1H3,(H,18,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Akebia Therapeutics, Inc. US Patent					Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...				US Patent US8598210 (2013) BindingDB Entry DOI: 10.7270/Q2M04428
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN3 (Homo sapiens (Human))	BDBM107701 (US8598210, Table XV, 7 | US8722895, 7: {[5-(2-Chlo...) Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-9(7-17-14)10-4-2-3-5-11(10)16/h2-7,19H,8H2,1H3,(H,18,21)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.75E+4	n/a	n/a	n/a	n/a	n/a	n/a
Akebia Therapeutics, Inc. US Patent					Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...				US Patent US8598210 (2013) BindingDB Entry DOI: 10.7270/Q2M04428
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM107701 (US8598210, Table XV, 7 | US8722895, 7: {[5-(2-Chlo...) Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-9(7-17-14)10-4-2-3-5-11(10)16/h2-7,19H,8H2,1H3,(H,18,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a
Akebia Therapeutics, Inc. US Patent					Assay Description HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...				US Patent US8598210 (2013) BindingDB Entry DOI: 10.7270/Q2M04428
					More data for this Ligand-Target Pair
Egl nine homolog 1 (Homo sapiens (Human))	BDBM107701 (US8598210, Table XV, 7 | US8722895, 7: {[5-(2-Chlo...) Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-9(7-17-14)10-4-2-3-5-11(10)16/h2-7,19H,8H2,1H3,(H,18,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	25
Akebia Therapeutics, Inc. US Patent					Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...				US Patent US8722895 (2014) BindingDB Entry DOI: 10.7270/Q25Q4TRQ
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN3 (Homo sapiens (Human))	BDBM107701 (US8598210, Table XV, 7 | US8722895, 7: {[5-(2-Chlo...) Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-9(7-17-14)10-4-2-3-5-11(10)16/h2-7,19H,8H2,1H3,(H,18,21)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.75E+4	n/a	n/a	n/a	n/a	n/a	25
Akebia Therapeutics, Inc. US Patent					Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...				US Patent US8722895 (2014) BindingDB Entry DOI: 10.7270/Q25Q4TRQ
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM107701 (US8598210, Table XV, 7 | US8722895, 7: {[5-(2-Chlo...) Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-9(7-17-14)10-4-2-3-5-11(10)16/h2-7,19H,8H2,1H3,(H,18,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a
University of California at Los Angeles					Assay Description HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...				Bioorg Med Chem 17: 7174-85 (2009) BindingDB Entry DOI: 10.7270/Q2D50Q9S
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN3 (Homo sapiens (Human))	BDBM107701 (US8598210, Table XV, 7 | US8722895, 7: {[5-(2-Chlo...) Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-9(7-17-14)10-4-2-3-5-11(10)16/h2-7,19H,8H2,1H3,(H,18,21)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.75E+4	n/a	n/a	n/a	n/a	n/a	n/a
Akebia Therapeutics, Inc. US Patent					Assay Description HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...				US Patent US9598370 (2017) BindingDB Entry DOI: 10.7270/Q20G3N64
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM107701 (US8598210, Table XV, 7 | US8722895, 7: {[5-(2-Chlo...) Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-9(7-17-14)10-4-2-3-5-11(10)16/h2-7,19H,8H2,1H3,(H,18,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a
Akebia Therapeutics, Inc. US Patent									US Patent US9598370 (2017) BindingDB Entry DOI: 10.7270/Q20G3N64
					More data for this Ligand-Target Pair
Egl nine homolog 1 (Homo sapiens (Human))	BDBM107701 (US8598210, Table XV, 7 | US8722895, 7: {[5-(2-Chlo...) Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-9(7-17-14)10-4-2-3-5-11(10)16/h2-7,19H,8H2,1H3,(H,18,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California at Los Angeles					Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...				Bioorg Med Chem 17: 7174-85 (2009) BindingDB Entry DOI: 10.7270/Q2D50Q9S
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN3 (Homo sapiens (Human))	BDBM107701 (US8598210, Table XV, 7 | US8722895, 7: {[5-(2-Chlo...) Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-9(7-17-14)10-4-2-3-5-11(10)16/h2-7,19H,8H2,1H3,(H,18,21)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.75E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California at Los Angeles					Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...				Bioorg Med Chem 17: 7174-85 (2009) BindingDB Entry DOI: 10.7270/Q2D50Q9S
					More data for this Ligand-Target Pair
Egl nine homolog 1 (Homo sapiens (Human))	BDBM107701 (US8598210, Table XV, 7 | US8722895, 7: {[5-(2-Chlo...) Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-9(7-17-14)10-4-2-3-5-11(10)16/h2-7,19H,8H2,1H3,(H,18,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Akebia Therapeutics, Inc. US Patent					Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...				US Patent US9598370 (2017) BindingDB Entry DOI: 10.7270/Q20G3N64
					More data for this Ligand-Target Pair