BDBM107712 US8598210, Table XV, 18::US8722895, 18: {[5-(3-Cyano-phenyl)-3-hydroxy-pyridine-2- carbonyl]-amino}-acetic acid methyl ester

SMILES: COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)[N+]#[C-]

InChI Key: InChIKey=UAWDTSDYMRFDAE-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 107712   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Egl nine homolog 1 (Homo sapiens (Human))	BDBM107712 (US8598210, Table XV, 18 | US8722895, 18: {[5-(3-Cy...) Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)[N+]#[C-] Show InChI InChI=1S/C16H13N3O4/c1-17-12-5-3-4-10(6-12)11-7-13(20)15(18-8-11)16(22)19-9-14(21)23-2/h3-8,20H,9H2,2H3,(H,19,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Akebia Therapeutics, Inc. US Patent					Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...				US Patent US8598210 (2013) BindingDB Entry DOI: 10.7270/Q2M04428
					More data for this Ligand-Target Pair
Egl nine homolog 1 (Homo sapiens (Human))	BDBM107712 (US8598210, Table XV, 18 | US8722895, 18: {[5-(3-Cy...) Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)[N+]#[C-] Show InChI InChI=1S/C16H13N3O4/c1-17-12-5-3-4-10(6-12)11-7-13(20)15(18-8-11)16(22)19-9-14(21)23-2/h3-8,20H,9H2,2H3,(H,19,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	25
Akebia Therapeutics, Inc. US Patent					Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...				US Patent US8722895 (2014) BindingDB Entry DOI: 10.7270/Q25Q4TRQ
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM107712 (US8598210, Table XV, 18 | US8722895, 18: {[5-(3-Cy...) Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)[N+]#[C-] Show InChI InChI=1S/C16H13N3O4/c1-17-12-5-3-4-10(6-12)11-7-13(20)15(18-8-11)16(22)19-9-14(21)23-2/h3-8,20H,9H2,2H3,(H,19,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Akebia Therapeutics, Inc. US Patent					Assay Description HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...				US Patent US8598210 (2013) BindingDB Entry DOI: 10.7270/Q2M04428
					More data for this Ligand-Target Pair