BDBM107718 US8598210, Table XV, 24::US8722895, 24: ({3-Hydroxy-5-[3-(2H-tetrazol-5-yl)phenyl]- pyridine-2-carbonyl}-amino)-acetic acid

SMILES: OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)-c1nnn[nH]1

InChI Key: InChIKey=JCWZYUTUSRZUAB-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 107718   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Egl nine homolog 1 (Homo sapiens (Human))	BDBM107718 (US8598210, Table XV, 24 | US8722895, 24: ({3-Hydro...) Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)-c1nnn[nH]1 Show InChI InChI=1S/C15H12N6O4/c22-11-5-10(6-16-13(11)15(25)17-7-12(23)24)8-2-1-3-9(4-8)14-18-20-21-19-14/h1-6,22H,7H2,(H,17,25)(H,23,24)(H,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Akebia Therapeutics, Inc. US Patent					Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...				US Patent US8598210 (2013) BindingDB Entry DOI: 10.7270/Q2M04428
					More data for this Ligand-Target Pair
Egl nine homolog 1 (Homo sapiens (Human))	BDBM107718 (US8598210, Table XV, 24 | US8722895, 24: ({3-Hydro...) Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)-c1nnn[nH]1 Show InChI InChI=1S/C15H12N6O4/c22-11-5-10(6-16-13(11)15(25)17-7-12(23)24)8-2-1-3-9(4-8)14-18-20-21-19-14/h1-6,22H,7H2,(H,17,25)(H,23,24)(H,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	25
Akebia Therapeutics, Inc. US Patent					Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...				US Patent US8722895 (2014) BindingDB Entry DOI: 10.7270/Q25Q4TRQ
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM107718 (US8598210, Table XV, 24 | US8722895, 24: ({3-Hydro...) Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)-c1nnn[nH]1 Show InChI InChI=1S/C15H12N6O4/c22-11-5-10(6-16-13(11)15(25)17-7-12(23)24)8-2-1-3-9(4-8)14-18-20-21-19-14/h1-6,22H,7H2,(H,17,25)(H,23,24)(H,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Akebia Therapeutics, Inc. US Patent					Assay Description HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...				US Patent US8598210 (2013) BindingDB Entry DOI: 10.7270/Q2M04428
					More data for this Ligand-Target Pair