BDBM107719 US8598210, Table XV, 25::US8722895, 25: ({5-[3-(cyclopropanecarbonyl-amino)- phenyl]-3-hydroxy-pyridine-2-carbonyl}- amino)-acetic acid methyl ester::US9598370, Example 00150::USRE47437, Example ({5-[3-(Cyclopropanecarbonyl-amino)-phenyl]-3-hydroxy-pyridine-2-carbonyl}-amino)-acetic acid methyl ester

SMILES: COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(NC(=O)C2CC2)c1

InChI Key: InChIKey=NJTATWKWAORKQP-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 107719   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Egl nine homolog 1 (Homo sapiens (Human))	BDBM107719 (US8598210, Table XV, 25 | US8722895, 25: ({5-[3-(c...) Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(NC(=O)C2CC2)c1 Show InChI InChI=1S/C19H19N3O5/c1-27-16(24)10-21-19(26)17-15(23)8-13(9-20-17)12-3-2-4-14(7-12)22-18(25)11-5-6-11/h2-4,7-9,11,23H,5-6,10H2,1H3,(H,21,26)(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Akebia Therapeutics, Inc. US Patent					Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...				US Patent US8598210 (2013) BindingDB Entry DOI: 10.7270/Q2M04428
					More data for this Ligand-Target Pair
Egl nine homolog 1 (Homo sapiens (Human))	BDBM107719 (US8598210, Table XV, 25 | US8722895, 25: ({5-[3-(c...) Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(NC(=O)C2CC2)c1 Show InChI InChI=1S/C19H19N3O5/c1-27-16(24)10-21-19(26)17-15(23)8-13(9-20-17)12-3-2-4-14(7-12)22-18(25)11-5-6-11/h2-4,7-9,11,23H,5-6,10H2,1H3,(H,21,26)(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California at Los Angeles					Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...				Bioorg Med Chem 17: 7174-85 (2009) BindingDB Entry DOI: 10.7270/Q2D50Q9S
					More data for this Ligand-Target Pair
Egl nine homolog 1 (Homo sapiens (Human))	BDBM107719 (US8598210, Table XV, 25 | US8722895, 25: ({5-[3-(c...) Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(NC(=O)C2CC2)c1 Show InChI InChI=1S/C19H19N3O5/c1-27-16(24)10-21-19(26)17-15(23)8-13(9-20-17)12-3-2-4-14(7-12)22-18(25)11-5-6-11/h2-4,7-9,11,23H,5-6,10H2,1H3,(H,21,26)(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Akebia Therapeutics, Inc. US Patent					Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...				US Patent US9598370 (2017) BindingDB Entry DOI: 10.7270/Q20G3N64
					More data for this Ligand-Target Pair
Egl nine homolog 1 (Homo sapiens (Human))	BDBM107719 (US8598210, Table XV, 25 | US8722895, 25: ({5-[3-(c...) Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(NC(=O)C2CC2)c1 Show InChI InChI=1S/C19H19N3O5/c1-27-16(24)10-21-19(26)17-15(23)8-13(9-20-17)12-3-2-4-14(7-12)22-18(25)11-5-6-11/h2-4,7-9,11,23H,5-6,10H2,1H3,(H,21,26)(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.20E+3	n/a	n/a	n/a	n/a	n/a	25
Akebia Therapeutics, Inc. US Patent					Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...				US Patent US8722895 (2014) BindingDB Entry DOI: 10.7270/Q25Q4TRQ
					More data for this Ligand-Target Pair