BDBM107749 US8598217, 84

SMILES: CN(C)Cc1ccc2nc([nH]c2c1)C(=O)c1ccnc(c1)-c1cncc2ccccc12

InChI Key: InChIKey=VLICGMIYFAGXFE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 107749   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 4 (Oryctolagus cuniculus (Rabbit))	BDBM107749 (US8598217, 84) Show SMILES CN(C)Cc1ccc2nc([nH]c2c1)C(=O)c1ccnc(c1)-c1cncc2ccccc12 Show InChI InChI=1S/C25H21N5O/c1-30(2)15-16-7-8-21-23(11-16)29-25(28-21)24(31)17-9-10-27-22(12-17)20-14-26-13-18-5-3-4-6-19(18)20/h3-14H,15H2,1-2H3,(H,28,29)	UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	57	n/a	n/a	n/a	n/a	7.5	n/a
Astex Therapeutics Ltd.; Novartis AG US Patent					Assay Description A 384-well microtiter Lance TR-FRET (time-resolved-fluorescence energy transfer) endpoint assay was used for CDK4/cyclin D1 kinase activity measureme...				US Patent US8598217 (2013) BindingDB Entry DOI: 10.7270/Q2BG2MN8
					More data for this Ligand-Target Pair