BDBM107754 US8598217, 103

SMILES: COc1ccc(F)c(F)c1-c1cc(ccn1)C(=O)c1nc2ccc(cc2[nH]1)N1CCC(CC1)N(C)C

InChI Key: InChIKey=QFPALJFKLKEVNR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 107754   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 4 (CDK4) (Oryctolagus cuniculus (Rabbit))	BDBM107754 (US8598217, 103) Show SMILES COc1ccc(F)c(F)c1-c1cc(ccn1)C(=O)c1nc2ccc(cc2[nH]1)N1CCC(CC1)N(C)C Show InChI InChI=1S/C27H27F2N5O2/c1-33(2)17-9-12-34(13-10-17)18-4-6-20-21(15-18)32-27(31-20)26(35)16-8-11-30-22(14-16)24-23(36-3)7-5-19(28)25(24)29/h4-8,11,14-15,17H,9-10,12-13H2,1-3H3,(H,31,32)	UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	60	n/a	n/a	n/a	n/a	7.5	n/a
Astex Therapeutics Ltd.; Novartis AG US Patent					Assay Description A 384-well microtiter Lance TR-FRET (time-resolved-fluorescence energy transfer) endpoint assay was used for CDK4/cyclin D1 kinase activity measureme...				US Patent US8598217 (2013) BindingDB Entry DOI: 10.7270/Q2BG2MN8
					More data for this Ligand-Target Pair