BDBM10783 1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-4-yl N,N-dimethylcarbamate::Aminoindan deriv. 23a::N-propargylaminoindan 23a

SMILES: CN(C)C(=O)Oc1cccc2C(CCc12)NCC#C

InChI Key: InChIKey=ACQQSVLNYFFGER-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 10783   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Acetylcholinesterase (Homo sapiens (Human))	BDBM10783 (1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-4-yl ...) Show SMILES CN(C)C(=O)Oc1cccc2C(CCc12)NCC#C Show InChI InChI=1S/C15H18N2O2/c1-4-10-16-13-9-8-12-11(13)6-5-7-14(12)19-15(18)17(2)3/h1,5-7,13,16H,8-10H2,2-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Teva Pharmaceutical Industries					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...				J Med Chem 45: 5260-79 (2002) Article DOI: 10.1021/jm020120c BindingDB Entry DOI: 10.7270/Q2GQ6W07
					More data for this Ligand-Target Pair
Monoamine Oxidase Type B (MAO-B) (Rattus norvegicus (rat))	BDBM10783 (1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-4-yl ...) Show SMILES CN(C)C(=O)Oc1cccc2C(CCc12)NCC#C Show InChI InChI=1S/C15H18N2O2/c1-4-10-16-13-9-8-12-11(13)6-5-7-14(12)19-15(18)17(2)3/h1,5-7,13,16H,8-10H2,2-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Teva Pharmaceutical Industries					Assay Description Inhibition of MAO activity was determined by a radiometric procedure from Tipton and Youdim. Homogenized rat brain was used as the source of enzymes....				J Med Chem 45: 5260-79 (2002) Article DOI: 10.1021/jm020120c BindingDB Entry DOI: 10.7270/Q2GQ6W07
					More data for this Ligand-Target Pair
Monoamine oxidase (Rattus norvegicus (rat))	BDBM10783 (1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-4-yl ...) Show SMILES CN(C)C(=O)Oc1cccc2C(CCc12)NCC#C Show InChI InChI=1S/C15H18N2O2/c1-4-10-16-13-9-8-12-11(13)6-5-7-14(12)19-15(18)17(2)3/h1,5-7,13,16H,8-10H2,2-3H3	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Teva Pharmaceutical Industries					Assay Description Inhibition of MAO activity was determined by a radiometric procedure from Tipton and Youdim. Homogenized rat brain was used as the source of enzymes....				J Med Chem 45: 5260-79 (2002) Article DOI: 10.1021/jm020120c BindingDB Entry DOI: 10.7270/Q2GQ6W07
					More data for this Ligand-Target Pair