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BDBM107849 US8598155, 8

SMILES: COc1ccc(-c2c(cnn2C)-c2nc(C)n3ncnc(N4CCC4)c23)c(C)c1

InChI Key: InChIKey=MRBSHEHZGHRREW-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 107849   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))		BDBM107849
PNG
(US8598155, 8)
Show SMILES COc1ccc(-c2c(cnn2C)-c2nc(C)n3ncnc(N4CCC4)c23)c(C)c1 |(6.83,-.36,;5.18,-1.42,;3.85,-.65,;2.52,-1.42,;1.18,-.65,;1.18,.89,;-.15,1.66,;-1.62,1.19,;-2.52,2.43,;-1.62,3.68,;-.15,3.2,;1.18,3.97,;-2.39,-.15,;-1.48,-1.39,;-2.39,-2.64,;-1.62,-3.97,;-3.85,-2.16,;-5.18,-2.93,;-6.52,-2.16,;-6.52,-.62,;-5.18,.15,;-5.18,1.69,;-6.52,2.46,;-5.75,3.79,;-4.41,3.02,;-3.85,-.62,;2.52,1.66,;2.52,3.2,;3.85,.89,)|
Show InChI InChI=1S/C21H23N7O/c1-13-10-15(29-4)6-7-16(13)19-17(11-23-26(19)3)18-20-21(27-8-5-9-27)22-12-24-28(20)14(2)25-18/h6-7,10-12H,5,8-9H2,1-4H3
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.578n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximity assay (SPA) modifie...

US Patent US8598155 (2013)


BindingDB Entry DOI: 10.7270/Q26T0K8C
More data for this
Ligand-Target Pair