BDBM108011 US8604218, 2.025

SMILES: Cc1ccc(CN2CC[C@H](C2)Nc2cccc3cnccc23)cc1

InChI Key: InChIKey=UQCGQZYLCBENSJ-LJQANCHMSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 108011   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM108011 (US8604218, 2.025) Show SMILES Cc1ccc(CN2CC[C@H](C2)Nc2cccc3cnccc23)cc1 |r| Show InChI InChI=1S/C21H23N3/c1-16-5-7-17(8-6-16)14-24-12-10-19(15-24)23-21-4-2-3-18-13-22-11-9-20(18)21/h2-9,11,13,19,23H,10,12,14-15H2,1H3/t19-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	29.9	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair