BDBM108059 N-carbamimidoyl-4-((4-((2,3-dimethyl-2H-indazole- 6-yl)(methyl)amino)pyrimidin-2-yl)amino) benzenesulfonamide (P2g)

SMILES: CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(cc2)S(=O)(=O)NC(N)=N)n1

InChI Key: InChIKey=UJVYCBGEGLRLHC-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 108059   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM108059 (N-carbamimidoyl-4-((4-((2,3-dimethyl-2H-indazole- ...) Show SMILES CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(cc2)S(=O)(=O)NC(N)=N)n1 Show InChI InChI=1S/C21H23N9O2S/c1-13-17-9-6-15(12-18(17)27-30(13)3)29(2)19-10-11-24-21(26-19)25-14-4-7-16(8-5-14)33(31,32)28-20(22)23/h4-12H,1-3H3,(H4,22,23,28)(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	720	n/a	n/a	n/a	n/a	n/a	25
Shandong Institute of Pharmaceutical Industry, Ji'nan, Shandong, 250101, China.					Assay Description To the assay kit, 2.5 µL of different concentrate of the test compounds, Pazopanib or water (control) were added and incubated for 1 h at room t...				Chem Biol Drug Des 83: 306-16 (2014) Article DOI: 10.1111/cbdd.12243 BindingDB Entry DOI: 10.7270/Q2PR7TM2
					More data for this Ligand-Target Pair
EGFR (Homo sapiens (Human))	BDBM108059 (N-carbamimidoyl-4-((4-((2,3-dimethyl-2H-indazole- ...) Show SMILES CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(cc2)S(=O)(=O)NC(N)=N)n1 Show InChI InChI=1S/C21H23N9O2S/c1-13-17-9-6-15(12-18(17)27-30(13)3)29(2)19-10-11-24-21(26-19)25-14-4-7-16(8-5-14)33(31,32)28-20(22)23/h4-12H,1-3H3,(H4,22,23,28)(H,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.37E+3	n/a	n/a	n/a	n/a	n/a	25
Shandong Institute of Pharmaceutical Industry, Ji'nan, Shandong, 250101, China.					Assay Description To the assay kit, 2.5 µL of different concentrate of the test compounds, Pazopanib or water (control) were added and incubated for 1 h at room t...				Chem Biol Drug Des 83: 306-16 (2014) Article DOI: 10.1111/cbdd.12243 BindingDB Entry DOI: 10.7270/Q2PR7TM2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM108059 (N-carbamimidoyl-4-((4-((2,3-dimethyl-2H-indazole- ...) Show SMILES CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(cc2)S(=O)(=O)NC(N)=N)n1 Show InChI InChI=1S/C21H23N9O2S/c1-13-17-9-6-15(12-18(17)27-30(13)3)29(2)19-10-11-24-21(26-19)25-14-4-7-16(8-5-14)33(31,32)28-20(22)23/h4-12H,1-3H3,(H4,22,23,28)(H,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	25
Shandong Institute of Pharmaceutical Industry, Ji'nan, Shandong, 250101, China.					Assay Description To the assay kit, 2.5 µL of different concentrate of the test compounds, Pazopanib or water (control) were added and incubated for 1 h at room t...				Chem Biol Drug Des 83: 306-16 (2014) Article DOI: 10.1111/cbdd.12243 BindingDB Entry DOI: 10.7270/Q2PR7TM2
					More data for this Ligand-Target Pair