BDBM108325 US8604046, 105

SMILES: C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCN(Cc4ccco4)CC3)C2=O)c(c1)C(F)(F)F

InChI Key: InChIKey=SAKZWHDDNTUCCS-GMAHTHKFSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 108325   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Macaca mulatta (Rhesus macaque))	BDBM108325 (US8604046, 105) Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCN(Cc4ccco4)CC3)C2=O)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C29H37F3N4O2/c1-21-4-2-12-35(21)23-8-13-34(19-23)22-6-7-26(25(18-22)29(30,31)32)36-16-11-28(27(36)37)9-14-33(15-10-28)20-24-5-3-17-38-24/h3,5-7,17-18,21,23H,2,4,8-16,19-20H2,1H3/t21-,23-/m0/s1	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi US Patent					Assay Description The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...				US Patent US8604046 (2013) BindingDB Entry DOI: 10.7270/Q2W957TB
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