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BDBM108991 US8604016, 573

SMILES: COC(=O)NCc1cccc(CC(=O)Nc2nnc(CCCCc3ccc(NC(=O)Cc4cccc(CNC(=O)OC)c4)nn3)s2)c1

InChI Key: InChIKey=OODJPFHOUMNNJM-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 108991   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM108991
PNG
(US8604016, 573)
Show SMILES COC(=O)NCc1cccc(CC(=O)Nc2nnc(CCCCc3ccc(NC(=O)Cc4cccc(CNC(=O)OC)c4)nn3)s2)c1
Show InChI InChI=1S/C32H36N8O6S/c1-45-31(43)33-19-23-9-5-7-21(15-23)17-27(41)35-26-14-13-25(37-38-26)11-3-4-12-29-39-40-30(47-29)36-28(42)18-22-8-6-10-24(16-22)20-34-32(44)46-2/h5-10,13-16H,3-4,11-12,17-20H2,1-2H3,(H,33,43)(H,34,44)(H,35,38,41)(H,36,40,42)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Calithera Biosciences Inc.

US Patent


Assay Description
Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...


US Patent US8604016 (2013)


BindingDB Entry DOI: 10.7270/Q2CC0ZBW
More data for this
Ligand-Target Pair