BindingDB logo
myBDB logout

null

SMILES: OCCNc1cc(nc2c(nc(nc12)N1CCOCC1)-c1cc(O)cc(F)c1)C(O)=O

InChI Key: InChIKey=CPUVSFXSWJQWSH-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 109296   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM109296
PNG
(US8609666, 16)
Show SMILES OCCNc1cc(nc2c(nc(nc12)N1CCOCC1)-c1cc(O)cc(F)c1)C(O)=O
Show InChI InChI=1S/C20H20FN5O5/c21-12-7-11(8-13(28)9-12)16-18-17(25-20(24-16)26-2-5-31-6-3-26)14(22-1-4-27)10-15(23-18)19(29)30/h7-10,27-28H,1-6H2,(H,22,23)(H,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 64n/an/an/an/an/an/a



Merck Serono SA

US Patent


Assay Description
The efficacy of compounds of the invention in inhibiting the PI3K induced-lipid phosphorylation may be tested in the following binding assay. The ass...

US Patent US8609666 (2013)


BindingDB Entry DOI: 10.7270/Q26M35G5
More data for this
Ligand-Target Pair