BDBM110118 US8609678, 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide [171]

SMILES: COc1cc2CCN(Cc2cc1OC)c1ncc(cn1)C(=O)NCCCCCCC(=O)NO

InChI Key: InChIKey=RFKMLYGYWJOZFF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 110118   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM110118 (US8609678, 2-(6,7-dimethoxy-3,4-dihydroisoquinolin...) Show SMILES COc1cc2CCN(Cc2cc1OC)c1ncc(cn1)C(=O)NCCCCCCC(=O)NO Show InChI InChI=1S/C23H31N5O5/c1-32-19-11-16-8-10-28(15-17(16)12-20(19)33-2)23-25-13-18(14-26-23)22(30)24-9-6-4-3-5-7-21(29)27-31/h11-14,31H,3-10,15H2,1-2H3,(H,24,30)(H,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	46	n/a	n/a	n/a	n/a	7.4	n/a
Acetylon Pharmaceuticals US Patent					Assay Description Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...				US Patent US8609678 (2013) BindingDB Entry DOI: 10.7270/Q25M64BS
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM110118 (US8609678, 2-(6,7-dimethoxy-3,4-dihydroisoquinolin...) Show SMILES COc1cc2CCN(Cc2cc1OC)c1ncc(cn1)C(=O)NCCCCCCC(=O)NO Show InChI InChI=1S/C23H31N5O5/c1-32-19-11-16-8-10-28(15-17(16)12-20(19)33-2)23-25-13-18(14-26-23)22(30)24-9-6-4-3-5-7-21(29)27-31/h11-14,31H,3-10,15H2,1-2H3,(H,24,30)(H,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	n/a
Acetylon Pharmaceuticals US Patent					Assay Description Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...				US Patent US8609678 (2013) BindingDB Entry DOI: 10.7270/Q25M64BS
					More data for this Ligand-Target Pair