BDBM11070 2-cyanopyrrolidine 24a::3-{[(2R,5S)-5-{[(2S)-2-cyanopyrrolidin-1-yl]carbonyl}pyrrolidin-2-yl]methyl}-1-phenylurea

SMILES: O=C(NC[C@H]1CC[C@H](N1)C(=O)N1CCC[C@H]1C#N)Nc1ccccc1

InChI Key: InChIKey=PORKEEGCMBVWKU-PMPSAXMXSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 11070   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM11070 (2-cyanopyrrolidine 24a | 3-{[(2R,5S)-5-{[(2S)-2-cy...) Show SMILES O=C(NC[C@H]1CC[C@H](N1)C(=O)N1CCC[C@H]1C#N)Nc1ccccc1 |r| Show InChI InChI=1S/C18H23N5O2/c19-11-15-7-4-10-23(15)17(24)16-9-8-14(21-16)12-20-18(25)22-13-5-2-1-3-6-13/h1-3,5-6,14-16,21H,4,7-10,12H2,(H2,20,22,25)/t14-,15+,16+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	15	-10.6	n/a	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The DPP4 activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and mea...				J Med Chem 49: 3520-35 (2006) Article DOI: 10.1021/jm051283e BindingDB Entry DOI: 10.7270/Q2WS8RG1
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