BDBM110759 US8614206, 292

SMILES: Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1N1CCC(N)CC(F)(F)C1

InChI Key: InChIKey=ITNAVUYPPJXDDX-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 110759   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM110759 (US8614206, 292) Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1N1CCC(N)CC(F)(F)C1 Show InChI InChI=1S/C22H24F3N7O/c1-31-21(32-9-8-13(26)10-22(24,25)12-32)18(11-28-31)30-20(33)19-16(27)6-7-17(29-19)14-4-2-3-5-15(14)23/h2-7,11,13H,8-10,12,26-27H2,1H3,(H,30,33)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.0210	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
F. Hoffmann-La Roche AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US8614206 (2013) BindingDB Entry DOI: 10.7270/Q2W66JFG
					More data for this Ligand-Target Pair