BDBM110857 US8614206, 408::US8614206, 409

SMILES: CNC1CCN(CC(F)(F)C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C

InChI Key: InChIKey=FBILCYLHVAXHSW-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 110857   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM110857 (US8614206, 408 | US8614206, 409) Show SMILES CNC1CCN(CC(F)(F)C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C Show InChI InChI=1S/C21H23F4N7OS/c1-27-11-6-7-32(10-21(24,25)8-11)20-14(9-28-31(20)2)29-18(33)16-17(26)34-19(30-16)15-12(22)4-3-5-13(15)23/h3-5,9,11,27H,6-8,10,26H2,1-2H3,(H,29,33)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.00700	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
F. Hoffmann-La Roche AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US8614206 (2013) BindingDB Entry DOI: 10.7270/Q2W66JFG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM110857 (US8614206, 408 | US8614206, 409) Show SMILES CNC1CCN(CC(F)(F)C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C Show InChI InChI=1S/C21H23F4N7OS/c1-27-11-6-7-32(10-21(24,25)8-11)20-14(9-28-31(20)2)29-18(33)16-17(26)34-19(30-16)15-12(22)4-3-5-13(15)23/h3-5,9,11,27H,6-8,10,26H2,1-2H3,(H,29,33)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.0140	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
F. Hoffmann-La Roche AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US8614206 (2013) BindingDB Entry DOI: 10.7270/Q2W66JFG
					More data for this Ligand-Target Pair