BDBM112471 US8623885, 12

SMILES: C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3cc4CN(CCO)CCc4cn3)nc12

InChI Key: InChIKey=CDKUUJPCCTYLGH-IRJFHVNHSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 112471   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 4 (Homo sapiens (Human))	BDBM112471 (US8623885, 12) Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3cc4CN(CCO)CCc4cn3)nc12 |r,wU:4.7,wD:1.0,(3.46,-3.21,;3.06,-1.73,;4.15,-.64,;3.75,.85,;2.27,1.25,;1.18,.16,;1.58,-1.33,;1.87,2.74,;2.77,3.98,;4.3,4.14,;4.93,5.55,;4.03,6.8,;2.49,6.64,;1.87,5.23,;.4,4.75,;-.93,5.52,;-2.26,4.75,;-2.26,3.21,;-3.6,2.44,;-3.6,.9,;-2.26,.13,;-2.26,-1.41,;-.93,-2.18,;-.93,-3.72,;.4,-4.49,;.4,-6.03,;1.74,-6.8,;-2.26,-4.49,;-3.6,-3.72,;-3.6,-2.18,;-4.93,-1.41,;-4.93,.13,;-.93,2.44,;.4,3.21,)| Show InChI InChI=1S/C26H31N7O/c1-17-2-4-20(5-3-17)33-23-15-27-8-6-21(23)22-14-29-26(31-25(22)33)30-24-12-19-16-32(10-11-34)9-7-18(19)13-28-24/h6,8,12-15,17,20,34H,2-5,7,9-11,16H2,1H3,(H,28,29,30,31)/t17-,20-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18.4	n/a	n/a	n/a	n/a	7.4	n/a
Amgen Inc. US Patent					Assay Description The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...				US Patent US8623885 (2014) BindingDB Entry DOI: 10.7270/Q2DZ06Z1
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM112471 (US8623885, 12) Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3cc4CN(CCO)CCc4cn3)nc12 |r,wU:4.7,wD:1.0,(3.46,-3.21,;3.06,-1.73,;4.15,-.64,;3.75,.85,;2.27,1.25,;1.18,.16,;1.58,-1.33,;1.87,2.74,;2.77,3.98,;4.3,4.14,;4.93,5.55,;4.03,6.8,;2.49,6.64,;1.87,5.23,;.4,4.75,;-.93,5.52,;-2.26,4.75,;-2.26,3.21,;-3.6,2.44,;-3.6,.9,;-2.26,.13,;-2.26,-1.41,;-.93,-2.18,;-.93,-3.72,;.4,-4.49,;.4,-6.03,;1.74,-6.8,;-2.26,-4.49,;-3.6,-3.72,;-3.6,-2.18,;-4.93,-1.41,;-4.93,.13,;-.93,2.44,;.4,3.21,)| Show InChI InChI=1S/C26H31N7O/c1-17-2-4-20(5-3-17)33-23-15-27-8-6-21(23)22-14-29-26(31-25(22)33)30-24-12-19-16-32(10-11-34)9-7-18(19)13-28-24/h6,8,12-15,17,20,34H,2-5,7,9-11,16H2,1H3,(H,28,29,30,31)/t17-,20-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	7.6	n/a
Amgen Inc. US Patent					Assay Description The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...				US Patent US8623885 (2014) BindingDB Entry DOI: 10.7270/Q2DZ06Z1
					More data for this Ligand-Target Pair