BDBM115425 US8637500, 294

SMILES: COCC(=O)N1CCC(CC1)c1cccnc1Oc1ccc(Nc2ccc(C)cn2)cc1

InChI Key: InChIKey=SOOQDEQDWKSDPO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 115425   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase Type 10 (PDE10A) (Rattus norvegicus (rat))	BDBM115425 (US8637500, 294) Show SMILES COCC(=O)N1CCC(CC1)c1cccnc1Oc1ccc(Nc2ccc(C)cn2)cc1 Show InChI InChI=1S/C25H28N4O3/c1-18-5-10-23(27-16-18)28-20-6-8-21(9-7-20)32-25-22(4-3-13-26-25)19-11-14-29(15-12-19)24(30)17-31-2/h3-10,13,16,19H,11-12,14-15,17H2,1-2H3,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.132	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...				US Patent US8637500 (2014) BindingDB Entry DOI: 10.7270/Q2XP73MV
					More data for this Ligand-Target Pair