BDBM11572 1b-ortho-F::5-(aminomethyl)-6-(2-fluorophenyl)-2-phenylpyrimidin-4-amine::Aminomethylpyrimidine 1bj
SMILES: NCc1c(N)nc(nc1-c1ccccc1F)-c1ccccc1
InChI Key: InChIKey=JGZBQNSUNNURPM-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM11572 (1b-ortho-F | 5-(aminomethyl)-6-(2-fluorophenyl)-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Hoffmann-La Roche Inc. | Assay Description DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a... | Bioorg Med Chem Lett 14: 1491-3 (2004) Article DOI: 10.1016/j.bmcl.2004.01.019 BindingDB Entry DOI: 10.7270/Q22B8W7M | |||||||||||
More data for this Ligand-Target Pair |