BDBM11587 1c-ortho-F::5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(2-fluorophenyl)pyrimidin-4-amine::Aminomethylpyrimidine 1ci

SMILES: NCc1c(N)nc(nc1-c1ccc(Cl)cc1Cl)-c1ccccc1F

InChI Key: InChIKey=RCYYITOQVYJJJX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 11587   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM11587 (1c-ortho-F | 5-(aminomethyl)-6-(2,4-dichlorophenyl...) Show SMILES NCc1c(N)nc(nc1-c1ccc(Cl)cc1Cl)-c1ccccc1F Show InChI InChI=1S/C17H13Cl2FN4/c18-9-5-6-10(13(19)7-9)15-12(8-21)16(22)24-17(23-15)11-3-1-2-4-14(11)20/h1-7H,8,21H2,(H2,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc.					Assay Description DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...				Bioorg Med Chem Lett 14: 1491-3 (2004) Article DOI: 10.1016/j.bmcl.2004.01.019 BindingDB Entry DOI: 10.7270/Q22B8W7M
					More data for this Ligand-Target Pair