BDBM11674 (2S,3S)-3-[3-(2-chloro-4-methanesulfonamidophenyl)-1,2,4-oxadiazol-5-yl]-1-(3,3-difluoropyrrolidin-1-yl)-1-oxobutan-2-aminium; 2,2,2-trifluoroacetate::alpha-amino acid pyrrolidide 36::oxadiazole based amide
SMILES: C[C@@H]([C@H]([NH3+])C(=O)N1CCC(F)(F)C1)c1nc(no1)-c1ccc(NS(C)(=O)=O)cc1Cl
InChI Key: InChIKey=IOGINJTZTHWKHC-ZANVPECISA-O
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM11674 ((2S,3S)-3-[3-(2-chloro-4-methanesulfonamidophenyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m... | Bioorg Med Chem Lett 16: 5373-7 (2006) Article DOI: 10.1016/j.bmcl.2006.07.061 BindingDB Entry DOI: 10.7270/Q2JD4V0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 9 (Homo sapiens (Human)) | BDBM11674 ((2S,3S)-3-[3-(2-chloro-4-methanesulfonamidophenyl)...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m... | Bioorg Med Chem Lett 16: 5373-7 (2006) Article DOI: 10.1016/j.bmcl.2006.07.061 BindingDB Entry DOI: 10.7270/Q2JD4V0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase VIII (Homo sapiens (Human)) | BDBM11674 ((2S,3S)-3-[3-(2-chloro-4-methanesulfonamidophenyl)...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m... | Bioorg Med Chem Lett 16: 5373-7 (2006) Article DOI: 10.1016/j.bmcl.2006.07.061 BindingDB Entry DOI: 10.7270/Q2JD4V0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human)) | BDBM11674 ((2S,3S)-3-[3-(2-chloro-4-methanesulfonamidophenyl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m... | Bioorg Med Chem Lett 16: 5373-7 (2006) Article DOI: 10.1016/j.bmcl.2006.07.061 BindingDB Entry DOI: 10.7270/Q2JD4V0K | |||||||||||
More data for this Ligand-Target Pair |