BDBM11718 (2S)-1-(2-{[4-(6,8-difluoro-1,2,3,4-tetrahydroisoquinolin-2-yl)-2-methyl-4-oxobutan-2-yl]amino}acetyl)pyrrolidine-2-carbonitrile::(2S)-Cyanopyrrolidine analogue 21c::2-[3-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-6,8-difluoro-1,2,3,4-tetrahydroisoquinoline

SMILES: CC(C)(CC(=O)N1CCc2cc(F)cc(F)c2C1)NCC(=O)N1CCC[C@H]1C#N

InChI Key: InChIKey=GPDZKJWJYYKLCJ-INIZCTEOSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 11718   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM11718 ((2S)-1-(2-{[4-(6,8-difluoro-1,2,3,4-tetrahydroisoq...) Show SMILES CC(C)(CC(=O)N1CCc2cc(F)cc(F)c2C1)NCC(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C21H26F2N4O2/c1-21(2,25-12-20(29)27-6-3-4-16(27)11-24)10-19(28)26-7-5-14-8-15(22)9-18(23)17(14)13-26/h8-9,16,25H,3-7,10,12-13H2,1-2H3/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes					Assay Description The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...				J Med Chem 49: 373-80 (2006) Article DOI: 10.1021/jm0507781 BindingDB Entry DOI: 10.7270/Q28W3BJH
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human))	BDBM11718 ((2S)-1-(2-{[4-(6,8-difluoro-1,2,3,4-tetrahydroisoq...) Show SMILES CC(C)(CC(=O)N1CCc2cc(F)cc(F)c2C1)NCC(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C21H26F2N4O2/c1-21(2,25-12-20(29)27-6-3-4-16(27)11-24)10-19(28)26-7-5-14-8-15(22)9-18(23)17(14)13-26/h8-9,16,25H,3-7,10,12-13H2,1-2H3/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.12E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes					Assay Description The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...				J Med Chem 49: 373-80 (2006) Article DOI: 10.1021/jm0507781 BindingDB Entry DOI: 10.7270/Q28W3BJH
					More data for this Ligand-Target Pair
Dipeptidyl peptidase VIII (Homo sapiens (Human))	BDBM11718 ((2S)-1-(2-{[4-(6,8-difluoro-1,2,3,4-tetrahydroisoq...) Show SMILES CC(C)(CC(=O)N1CCc2cc(F)cc(F)c2C1)NCC(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C21H26F2N4O2/c1-21(2,25-12-20(29)27-6-3-4-16(27)11-24)10-19(28)26-7-5-14-8-15(22)9-18(23)17(14)13-26/h8-9,16,25H,3-7,10,12-13H2,1-2H3/t16-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes					Assay Description The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...				J Med Chem 49: 373-80 (2006) Article DOI: 10.1021/jm0507781 BindingDB Entry DOI: 10.7270/Q28W3BJH
					More data for this Ligand-Target Pair