BDBM119215 US8673938, 68

SMILES: CCCSc1nc(ccc1C(=O)NC1C2CC3CC(C2)CC1C3)N1CCOC(C1)C(O)=O

InChI Key: InChIKey=UTTJDSDFBCWGMB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 119215   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM119215 (US8673938, 68) Show SMILES CCCSc1nc(ccc1C(=O)NC1C2CC3CC(C2)CC1C3)N1CCOC(C1)C(O)=O |THB:20:18:15:21.13.22,17:18:13:15.16.22,(2.67,-4.23,;2.67,-2.69,;1.33,-1.93,;1.33,-.38,;,.38,;-1.33,-.38,;-2.67,.38,;-2.67,1.93,;-1.33,2.69,;,1.93,;1.33,2.69,;1.33,4.23,;2.67,1.93,;4,2.69,;5.33,1.93,;6.67,2.69,;6.67,4.23,;6,3.39,;5.23,3.39,;4.86,2.91,;5.23,4.22,;4,4.23,;5.33,5,;-4,-.38,;-5.33,.38,;-6.67,-.38,;-6.67,-1.93,;-5.33,-2.69,;-4,-1.93,;-5.33,-4.23,;-4,-5,;-6.67,-5,)| Show InChI InChI=1S/C24H33N3O4S/c1-2-7-32-23-18(3-4-20(25-23)27-5-6-31-19(13-27)24(29)30)22(28)26-21-16-9-14-8-15(11-16)12-17(21)10-14/h3-4,14-17,19,21H,2,5-13H2,1H3,(H,26,28)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The conversion of cortisone to the active steroid cortisol by 11βHSD1 oxo-reductase activity, can be measured using a competitive homogeneous ti...				US Patent US8673938 (2014) BindingDB Entry DOI: 10.7270/Q2610Z0D
					More data for this Ligand-Target Pair