BDBM119484 US8680275, 17::US8680275, 8

SMILES: O=C(N1CCC2CN(C2C1)c1cnc2ccccc2n1)c1ccccc1-c1ccccc1

InChI Key: InChIKey=HWBHNCKNXGKGOR-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 119484   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM119484 (US8680275, 17 | US8680275, 8) Show SMILES O=C(N1CCC2CN(C2C1)c1cnc2ccccc2n1)c1ccccc1-c1ccccc1 Show InChI InChI=1S/C27H24N4O/c32-27(22-11-5-4-10-21(22)19-8-2-1-3-9-19)30-15-14-20-17-31(25(20)18-30)26-16-28-23-12-6-7-13-24(23)29-26/h1-13,16,20,25H,14-15,17-18H2	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	24	-9.66	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM119484 (US8680275, 17 | US8680275, 8) Show SMILES O=C(N1CCC2CN(C2C1)c1cnc2ccccc2n1)c1ccccc1-c1ccccc1 Show InChI InChI=1S/C27H24N4O/c32-27(22-11-5-4-10-21(22)19-8-2-1-3-9-19)30-15-14-20-17-31(25(20)18-30)26-16-28-23-12-6-7-13-24(23)29-26/h1-13,16,20,25H,14-15,17-18H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	24	-9.66	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM119484 (US8680275, 17 | US8680275, 8) Show SMILES O=C(N1CCC2CN(C2C1)c1cnc2ccccc2n1)c1ccccc1-c1ccccc1 Show InChI InChI=1S/C27H24N4O/c32-27(22-11-5-4-10-21(22)19-8-2-1-3-9-19)30-15-14-20-17-31(25(20)18-30)26-16-28-23-12-6-7-13-24(23)29-26/h1-13,16,20,25H,14-15,17-18H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	305	-8.26	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM119484 (US8680275, 17 | US8680275, 8) Show SMILES O=C(N1CCC2CN(C2C1)c1cnc2ccccc2n1)c1ccccc1-c1ccccc1 Show InChI InChI=1S/C27H24N4O/c32-27(22-11-5-4-10-21(22)19-8-2-1-3-9-19)30-15-14-20-17-31(25(20)18-30)26-16-28-23-12-6-7-13-24(23)29-26/h1-13,16,20,25H,14-15,17-18H2	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	542	-7.94	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair