BDBM119638 US8680275, 195

SMILES: Cc1ccc(c(c1)C(=O)N1CC[C@H]2CN([C@H]2C1)c1ccnc(n1)-c1ccccc1)C(F)(F)F

InChI Key: InChIKey=PRZINKCNQUYNTL-RXVVDRJESA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 119638   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 1 (Homo sapiens (Human))	BDBM119638 (US8680275, 195) Show SMILES Cc1ccc(c(c1)C(=O)N1CC[C@H]2CN([C@H]2C1)c1ccnc(n1)-c1ccccc1)C(F)(F)F |r| Show InChI InChI=1S/C25H23F3N4O/c1-16-7-8-20(25(26,27)28)19(13-16)24(33)31-12-10-18-14-32(21(18)15-31)22-9-11-29-23(30-22)17-5-3-2-4-6-17/h2-9,11,13,18,21H,10,12,14-15H2,1H3/t18-,21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	16	-9.88	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM119638 (US8680275, 195) Show SMILES Cc1ccc(c(c1)C(=O)N1CC[C@H]2CN([C@H]2C1)c1ccnc(n1)-c1ccccc1)C(F)(F)F |r| Show InChI InChI=1S/C25H23F3N4O/c1-16-7-8-20(25(26,27)28)19(13-16)24(33)31-12-10-18-14-32(21(18)15-31)22-9-11-29-23(30-22)17-5-3-2-4-6-17/h2-9,11,13,18,21H,10,12,14-15H2,1H3/t18-,21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	28	-9.57	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair