BDBM119639 US8680275, 196

SMILES: FC(F)C(F)(F)Oc1ccccc1C(=O)N1CC[C@H]2CN([C@H]2C1)c1ccnc(n1)-c1ccccc1

InChI Key: InChIKey=DSJBLNQBTFEBSJ-HKUYNNGSSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 119639   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 1 (Homo sapiens (Human))	BDBM119639 (US8680275, 196) Show SMILES FC(F)C(F)(F)Oc1ccccc1C(=O)N1CC[C@H]2CN([C@H]2C1)c1ccnc(n1)-c1ccccc1 |r| Show InChI InChI=1S/C25H22F4N4O2/c26-24(27)25(28,29)35-20-9-5-4-8-18(20)23(34)32-13-11-17-14-33(19(17)15-32)21-10-12-30-22(31-21)16-6-2-1-3-7-16/h1-10,12,17,19,24H,11,13-15H2/t17-,19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	14	-9.95	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM119639 (US8680275, 196) Show SMILES FC(F)C(F)(F)Oc1ccccc1C(=O)N1CC[C@H]2CN([C@H]2C1)c1ccnc(n1)-c1ccccc1 |r| Show InChI InChI=1S/C25H22F4N4O2/c26-24(27)25(28,29)35-20-9-5-4-8-18(20)23(34)32-13-11-17-14-33(19(17)15-32)21-10-12-30-22(31-21)16-6-2-1-3-7-16/h1-10,12,17,19,24H,11,13-15H2/t17-,19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	14	-9.95	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair