BDBM119645 US8680275, 5

SMILES: O=C(N1CCC2CN(C2C1)c1cnc2ccccc2n1)c1ccccc1-c1ccco1

InChI Key: InChIKey=CJWALWGZPZBUMF-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 119645   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 1 (Homo sapiens (Human))	BDBM119645 (US8680275, 5) Show SMILES O=C(N1CCC2CN(C2C1)c1cnc2ccccc2n1)c1ccccc1-c1ccco1 Show InChI InChI=1S/C25H22N4O2/c30-25(19-7-2-1-6-18(19)23-10-5-13-31-23)28-12-11-17-15-29(22(17)16-28)24-14-26-20-8-3-4-9-21(20)27-24/h1-10,13-14,17,22H,11-12,15-16H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	8	-10.3	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM119645 (US8680275, 5) Show SMILES O=C(N1CCC2CN(C2C1)c1cnc2ccccc2n1)c1ccccc1-c1ccco1 Show InChI InChI=1S/C25H22N4O2/c30-25(19-7-2-1-6-18(19)23-10-5-13-31-23)28-12-11-17-15-29(22(17)16-28)24-14-26-20-8-3-4-9-21(20)27-24/h1-10,13-14,17,22H,11-12,15-16H2	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	10	-10.1	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair