BDBM119653 US8680275, 22

SMILES: Cc1cc(C)nc(n1)N1CC2CCN(CC12)C(=O)c1c(F)cccc1-c1ncccn1

InChI Key: InChIKey=GRZCUNDJSTYPFU-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 119653   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM119653 (US8680275, 22) Show SMILES Cc1cc(C)nc(n1)N1CC2CCN(CC12)C(=O)c1c(F)cccc1-c1ncccn1 Show InChI InChI=1S/C23H23FN6O/c1-14-11-15(2)28-23(27-14)30-12-16-7-10-29(13-19(16)30)22(31)20-17(5-3-6-18(20)24)21-25-8-4-9-26-21/h3-6,8-9,11,16,19H,7,10,12-13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	29	-9.55	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM119653 (US8680275, 22) Show SMILES Cc1cc(C)nc(n1)N1CC2CCN(CC12)C(=O)c1c(F)cccc1-c1ncccn1 Show InChI InChI=1S/C23H23FN6O/c1-14-11-15(2)28-23(27-14)30-12-16-7-10-29(13-19(16)30)22(31)20-17(5-3-6-18(20)24)21-25-8-4-9-26-21/h3-6,8-9,11,16,19H,7,10,12-13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	473	-8.02	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair