BDBM119654 US8680275, 23

SMILES: Cc1cc(C)nc(n1)N1CC2CCN(CC12)C(=O)c1cc(F)ccc1-c1ncccn1

InChI Key: InChIKey=URROPVKRCHCUOU-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 119654   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM119654 (US8680275, 23) Show SMILES Cc1cc(C)nc(n1)N1CC2CCN(CC12)C(=O)c1cc(F)ccc1-c1ncccn1 Show InChI InChI=1S/C23H23FN6O/c1-14-10-15(2)28-23(27-14)30-12-16-6-9-29(13-20(16)30)22(31)19-11-17(24)4-5-18(19)21-25-7-3-8-26-21/h3-5,7-8,10-11,16,20H,6,9,12-13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	20	-9.76	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM119654 (US8680275, 23) Show SMILES Cc1cc(C)nc(n1)N1CC2CCN(CC12)C(=O)c1cc(F)ccc1-c1ncccn1 Show InChI InChI=1S/C23H23FN6O/c1-14-10-15(2)28-23(27-14)30-12-16-6-9-29(13-20(16)30)22(31)19-11-17(24)4-5-18(19)21-25-7-3-8-26-21/h3-5,7-8,10-11,16,20H,6,9,12-13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	619	-7.87	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair