BDBM119662 US8680275, 32

SMILES: Cc1cc(nc(C)n1)N1CC2CCN(CC12)C(=O)c1c(F)cccc1-n1nccn1

InChI Key: InChIKey=NTJZTWQASWQMOZ-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 119662   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM119662 (US8680275, 32) Show SMILES Cc1cc(nc(C)n1)N1CC2CCN(CC12)C(=O)c1c(F)cccc1-n1nccn1 Show InChI InChI=1S/C21H22FN7O/c1-13-10-19(26-14(2)25-13)28-11-15-6-9-27(12-18(15)28)21(30)20-16(22)4-3-5-17(20)29-23-7-8-24-29/h3-5,7-8,10,15,18H,6,9,11-12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	13	-9.99	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM119662 (US8680275, 32) Show SMILES Cc1cc(nc(C)n1)N1CC2CCN(CC12)C(=O)c1c(F)cccc1-n1nccn1 Show InChI InChI=1S/C21H22FN7O/c1-13-10-19(26-14(2)25-13)28-11-15-6-9-27(12-18(15)28)21(30)20-16(22)4-3-5-17(20)29-23-7-8-24-29/h3-5,7-8,10,15,18H,6,9,11-12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	134	-8.71	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair