BDBM119665 US8680275, 35

SMILES: Cc1cc(nc(n1)C(F)(F)F)N1CC2CCN(CC12)C(=O)c1ccccc1-n1nccn1

InChI Key: InChIKey=XVYQCSDBLWBGHX-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 119665   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM119665 (US8680275, 35) Show SMILES Cc1cc(nc(n1)C(F)(F)F)N1CC2CCN(CC12)C(=O)c1ccccc1-n1nccn1 Show InChI InChI=1S/C21H20F3N7O/c1-13-10-18(28-20(27-13)21(22,23)24)30-11-14-6-9-29(12-17(14)30)19(32)15-4-2-3-5-16(15)31-25-7-8-26-31/h2-5,7-8,10,14,17H,6,9,11-12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	24	-9.66	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM119665 (US8680275, 35) Show SMILES Cc1cc(nc(n1)C(F)(F)F)N1CC2CCN(CC12)C(=O)c1ccccc1-n1nccn1 Show InChI InChI=1S/C21H20F3N7O/c1-13-10-18(28-20(27-13)21(22,23)24)30-11-14-6-9-29(12-17(14)30)19(32)15-4-2-3-5-16(15)31-25-7-8-26-31/h2-5,7-8,10,14,17H,6,9,11-12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	117	-8.78	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair