BDBM119675 US8680275, 270

SMILES: Cc1nc(nc(C)c1C)N1C[C@@H]2CCN(C[C@H]12)C(=O)c1ccccc1-n1nccn1

InChI Key: InChIKey=HXGLBRDCFKNXJH-PXNSSMCTSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 119675   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM119675 (US8680275, 270) Show SMILES Cc1nc(nc(C)c1C)N1C[C@@H]2CCN(C[C@H]12)C(=O)c1ccccc1-n1nccn1 |r| Show InChI InChI=1S/C22H25N7O/c1-14-15(2)25-22(26-16(14)3)28-12-17-8-11-27(13-20(17)28)21(30)18-6-4-5-7-19(18)29-23-9-10-24-29/h4-7,9-10,17,20H,8,11-13H2,1-3H3/t17-,20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	11	-10.1	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM119675 (US8680275, 270) Show SMILES Cc1nc(nc(C)c1C)N1C[C@@H]2CCN(C[C@H]12)C(=O)c1ccccc1-n1nccn1 |r| Show InChI InChI=1S/C22H25N7O/c1-14-15(2)25-22(26-16(14)3)28-12-17-8-11-27(13-20(17)28)21(30)18-6-4-5-7-19(18)29-23-9-10-24-29/h4-7,9-10,17,20H,8,11-13H2,1-3H3/t17-,20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	16	-9.88	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM119675 (US8680275, 270) Show SMILES Cc1nc(nc(C)c1C)N1C[C@@H]2CCN(C[C@H]12)C(=O)c1ccccc1-n1nccn1 |r| Show InChI InChI=1S/C22H25N7O/c1-14-15(2)25-22(26-16(14)3)28-12-17-8-11-27(13-20(17)28)21(30)18-6-4-5-7-19(18)29-23-9-10-24-29/h4-7,9-10,17,20H,8,11-13H2,1-3H3/t17-,20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	5.40E+3	-6.68	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair