BDBM120131 US8697708, 16
SMILES: Fc1cccc(Cl)c1-c1nc2ccnc(NC(=O)NC3CC3)c2s1
InChI Key: InChIKey=RVEDWGQSRXHPDZ-UHFFFAOYSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM120131 (US8697708, 16) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.40 | -11.9 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
F. Hoffmann-La Roche AG US Patent | Assay Description To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai... | US Patent US8697708 (2014) BindingDB Entry DOI: 10.7270/Q2J38R6F | |||||||||||
More data for this Ligand-Target Pair |