BDBM120520 US8703768, 120

SMILES: CC(C)(O)CNC(=O)c1cnccc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1

InChI Key: InChIKey=DUOXLNANFGKAHS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 120520   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120520 (US8703768, 120) Show SMILES CC(C)(O)CNC(=O)c1cnccc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C22H24N8O3/c1-22(2,33)11-27-20(31)15-9-23-6-5-16(15)30-21(32)18-19(28-14-7-24-12-25-8-14)26-10-17(29-18)13-3-4-13/h5-10,12-13,33H,3-4,11H2,1-2H3,(H,26,28)(H,27,31)(H,23,30,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description PDE10 activity of the compounds of the present invention was determined using a Scintillation Proximity Assay (SPA)-based method similar to the one p...				US Patent US8703768 (2014) BindingDB Entry DOI: 10.7270/Q27P8X37
					More data for this Ligand-Target Pair