BDBM120609 US8703768, 210

SMILES: COCc1ccc(NC(=O)c2nc(cnc2Nc2cncnc2)C2CC2)c(n1)C(=O)NCC(C)(C)O

InChI Key: InChIKey=STDUGXCJNBFARO-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 120609   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120609 (US8703768, 210) Show SMILES COCc1ccc(NC(=O)c2nc(cnc2Nc2cncnc2)C2CC2)c(n1)C(=O)NCC(C)(C)O Show InChI InChI=1S/C24H28N8O4/c1-24(2,35)12-28-22(33)19-17(7-6-15(29-19)11-36-3)32-23(34)20-21(30-16-8-25-13-26-9-16)27-10-18(31-20)14-4-5-14/h6-10,13-14,35H,4-5,11-12H2,1-3H3,(H,27,30)(H,28,33)(H,32,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description PDE10 activity of the compounds of the present invention was determined using a Scintillation Proximity Assay (SPA)-based method similar to the one p...				US Patent US8703768 (2014) BindingDB Entry DOI: 10.7270/Q27P8X37
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