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BDBM120818 (E)-5-(((3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl) propoxy)quinolin-4-yl)oxy)phenyl)amino)methylene)-1-methyl-3-(2- (trifluoromethyl)phenyl)imidazolidine-2,4-dione (38)

SMILES: COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccccc4C(F)(F)F)c(=O)n3C)ccnc2cc1OCCCN1CCCC1

InChI Key: InChIKey=KYHVVHYUNQTQND-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 120818   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM120818
PNG
((E)-5-(((3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccccc4C(F)(F)F)c(=O)n3C)ccnc2cc1OCCCN1CCCC1 |w:14.14,(-7.96,1.65,;-6.63,2.42,;-5.29,1.65,;-3.96,2.42,;-2.63,1.65,;-1.29,2.42,;-1.29,3.96,;.04,4.73,;1.37,3.96,;2.71,4.73,;2.71,6.27,;1.37,7.04,;.04,6.27,;-1.29,7.04,;4.04,7.04,;5.38,6.27,;6.71,7.04,;6.87,8.57,;5.73,9.6,;8.38,8.89,;9,10.3,;10.53,10.46,;11.16,11.87,;10.26,13.11,;8.72,12.95,;8.1,11.54,;6.57,11.38,;5.23,10.61,;6.09,12.85,;7.04,9.92,;9.15,7.56,;10.68,7.4,;8.12,6.41,;8.44,4.91,;.04,1.65,;.04,.11,;-1.29,-.66,;-2.63,.11,;-3.96,-.66,;-5.29,.11,;-6.63,-.66,;-7.96,.11,;-9.29,-.66,;-10.63,.11,;-11.96,-.66,;-13.37,-.03,;-14.4,-1.18,;-13.63,-2.51,;-12.12,-2.19,)|
Show InChI InChI=1S/C35H33F4N5O5/c1-42-28(33(45)44(34(42)46)27-9-4-3-8-24(27)35(37,38)39)21-41-22-10-11-30(25(36)18-22)49-29-12-13-40-26-20-32(31(47-2)19-23(26)29)48-17-7-16-43-14-5-6-15-43/h3-4,8-13,18-21,45H,5-7,14-17H2,1-2H3
PDB
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KEGG

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Similars
Article
PubMed
n/an/a 2.75n/an/an/an/a7.025



Shenyang Pharmaceutical University, Ministry of Education



Assay Description
The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...

Bioorg Chem 57: 30-42 (2014)


Article DOI: 10.1016/j.bioorg.2014.07.011
BindingDB Entry DOI: 10.7270/Q2BG2MPQ
More data for this
Ligand-Target Pair