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BDBM120819 (E)-5-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopropoxy) quinolin-4-yl)oxy)phenyl)amino)m ethylene)-3-(2-fluorophenyl)-1- methylimidazolidine-2,4-dione (40)

SMILES: COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccccc4F)c(=O)n3C)ccnc2cc1OCCCN1CCOCC1

InChI Key: InChIKey=RXUZOEZKSWKIQG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 120819   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM120819
PNG
((E)-5-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccccc4F)c(=O)n3C)ccnc2cc1OCCCN1CCOCC1 |w:14.14,(-7.96,1.65,;-6.63,2.42,;-5.29,1.65,;-3.96,2.42,;-2.63,1.65,;-1.29,2.42,;-1.29,3.96,;.04,4.73,;1.37,3.96,;2.71,4.73,;2.71,6.27,;1.37,7.04,;.04,6.27,;-1.29,7.04,;4.04,7.04,;5.38,6.27,;6.71,7.04,;6.87,8.57,;5.73,9.6,;8.38,8.89,;9,10.3,;10.53,10.46,;11.16,11.87,;10.26,13.11,;8.72,12.95,;8.1,11.54,;6.57,11.38,;9.15,7.56,;10.68,7.4,;8.12,6.41,;8.44,4.91,;.04,1.65,;.04,.11,;-1.29,-.66,;-2.63,.11,;-3.96,-.66,;-5.29,.11,;-6.63,-.66,;-7.96,.11,;-9.29,-.66,;-10.63,.11,;-11.96,-.66,;-13.3,.11,;-14.63,-.66,;-14.63,-2.2,;-13.3,-2.97,;-11.96,-2.2,)|
Show InChI InChI=1S/C34H33F2N5O6/c1-39-28(33(42)41(34(39)43)27-7-4-3-6-24(27)35)21-38-22-8-9-30(25(36)18-22)47-29-10-11-37-26-20-32(31(44-2)19-23(26)29)46-15-5-12-40-13-16-45-17-14-40/h3-4,6-11,18-21,42H,5,12-17H2,1-2H3
PDB
MMDB

KEGG

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PC cid
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Similars
Article
PubMed
n/an/a 8.78n/an/an/an/a7.025



Shenyang Pharmaceutical University, Ministry of Education



Assay Description
The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...

Bioorg Chem 57: 30-42 (2014)


Article DOI: 10.1016/j.bioorg.2014.07.011
BindingDB Entry DOI: 10.7270/Q2BG2MPQ
More data for this
Ligand-Target Pair