BDBM120965 US8716285, 22

SMILES: ONC(=O)c1ccc2CCC(Cc2c1)Nc1nccc(n1)-c1ccc(F)c(Cl)c1

InChI Key: InChIKey=BMSKLNYSPWXBNM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 120965   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 8 (Homo sapiens (Human))	BDBM120965 (US8716285, 22) Show SMILES ONC(=O)c1ccc2CCC(Cc2c1)Nc1nccc(n1)-c1ccc(F)c(Cl)c1 Show InChI InChI=1S/C21H18ClFN4O2/c22-17-11-13(4-6-18(17)23)19-7-8-24-21(26-19)25-16-5-3-12-1-2-14(20(28)27-29)9-15(12)10-16/h1-2,4,6-9,11,16,29H,3,5,10H2,(H,27,28)(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Compounds were tested for their ability to inhibit histone deacetylase 8 using an in vitro deacetylation assay. In a detailed procedure, 8 μl o...				US Patent US8716285 (2014) BindingDB Entry DOI: 10.7270/Q2K072XG
					More data for this Ligand-Target Pair