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SMILES: ONC(=O)c1ccc2CCC(Cc2c1)NC(=O)\C=C\c1cccnc1

InChI Key: InChIKey=VBUXSOAWYYYHLJ-FPYGCLRLSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 120980   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase 8


(Homo sapiens (Human))		BDBM120980
PNG
(US8716285, 37)
Show SMILES ONC(=O)c1ccc2CCC(Cc2c1)NC(=O)\C=C\c1cccnc1
Show InChI InChI=1S/C19H19N3O3/c23-18(8-3-13-2-1-9-20-12-13)21-17-7-6-14-4-5-15(19(24)22-25)10-16(14)11-17/h1-5,8-10,12,17,25H,6-7,11H2,(H,21,23)(H,22,24)/b8-3+
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PC cid
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US Patent
n/an/a 990n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Compounds were tested for their ability to inhibit histone deacetylase 8 using an in vitro deacetylation assay. In a detailed procedure, 8 μl o...

US Patent US8716285 (2014)


BindingDB Entry DOI: 10.7270/Q2K072XG
More data for this
Ligand-Target Pair