BDBM120989 US8716285, 46

SMILES: ONC(=O)c1ccc2CCC(Cc2c1)NS(=O)(=O)c1ccc(Cl)cc1Cl

InChI Key: InChIKey=MMWCXKKKWHQVNU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 120989   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 8 (Homo sapiens (Human))	BDBM120989 (US8716285, 46) Show SMILES ONC(=O)c1ccc2CCC(Cc2c1)NS(=O)(=O)c1ccc(Cl)cc1Cl Show InChI InChI=1S/C17H16Cl2N2O4S/c18-13-4-6-16(15(19)9-13)26(24,25)21-14-5-3-10-1-2-11(17(22)20-23)7-12(10)8-14/h1-2,4,6-7,9,14,21,23H,3,5,8H2,(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Compounds were tested for their ability to inhibit histone deacetylase 8 using an in vitro deacetylation assay. In a detailed procedure, 8 μl o...				US Patent US8716285 (2014) BindingDB Entry DOI: 10.7270/Q2K072XG
					More data for this Ligand-Target Pair