BindingDB PrimarySearch

BDBM121202 US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide::US8722896, (+/-)-2-Methyl-3-(indol-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide::US8722896, (-)-(2R)-2-Methyl-3-(indol-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide

SMILES: CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc2[nH]ccc12

InChI Key: InChIKey=WVARBMDYVFPBSM-UHFFFAOYSA-N

Data: 14 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 121202
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Prokineticin receptor 2 (PRK2) (Cricetulus griseus (Chinese hamster))	BDBM121202 (US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethyla...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.43	-12.5	n/a	n/a	n/a	n/a	n/a	n/a	37
The Regents of the University of California US Patent					Assay Description An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...				US Patent US8722896 (2014) BindingDB Entry DOI: 10.7270/Q29G5KGF
The Regents of the University of California US Patent					More data for this Ligand-Target Pair
Prokineticin receptor 2 (PRK2) (Cricetulus griseus (Chinese hamster))	BDBM121202 (US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethyla...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.5	-12.5	n/a	n/a	n/a	n/a	n/a	n/a	37
The Regents of the University of California US Patent					Assay Description An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...				US Patent US8722896 (2014) BindingDB Entry DOI: 10.7270/Q29G5KGF
The Regents of the University of California US Patent					More data for this Ligand-Target Pair
Prokineticin receptor 2 (PRK2) (Cricetulus griseus (Chinese hamster))	BDBM121202 (US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethyla...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.60	-12.5	n/a	n/a	n/a	n/a	n/a	n/a	37
The Regents of the University of California US Patent					Assay Description An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...				US Patent US8722896 (2014) BindingDB Entry DOI: 10.7270/Q29G5KGF
The Regents of the University of California US Patent					More data for this Ligand-Target Pair
Prokineticin receptor 1 (PRK1) (Cricetulus griseus (Chinese hamster))	BDBM121202 (US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethyla...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.38	-12.2	n/a	n/a	n/a	n/a	n/a	n/a	37
The Regents of the University of California US Patent					Assay Description An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...				US Patent US8722896 (2014) BindingDB Entry DOI: 10.7270/Q29G5KGF
The Regents of the University of California US Patent					More data for this Ligand-Target Pair
Prokineticin receptor 2 (PRK2) (Cricetulus griseus (Chinese hamster))	BDBM121202 (US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethyla...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.62	-12.2	n/a	n/a	n/a	n/a	n/a	n/a	37
The Regents of the University of California US Patent					Assay Description An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...				US Patent US8722896 (2014) BindingDB Entry DOI: 10.7270/Q29G5KGF
The Regents of the University of California US Patent					More data for this Ligand-Target Pair
Prokineticin receptor 1 (PRK1) (Cricetulus griseus (Chinese hamster))	BDBM121202 (US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethyla...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	4.08	-11.9	n/a	n/a	n/a	n/a	n/a	n/a	37
The Regents of the University of California US Patent					Assay Description An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...				US Patent US8722896 (2014) BindingDB Entry DOI: 10.7270/Q29G5KGF
The Regents of the University of California US Patent					More data for this Ligand-Target Pair
Prokineticin receptor 1 (PRK1) (Cricetulus griseus (Chinese hamster))	BDBM121202 (US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethyla...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	4.24	-11.9	n/a	n/a	n/a	n/a	n/a	n/a	37
The Regents of the University of California US Patent					Assay Description An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...				US Patent US8722896 (2014) BindingDB Entry DOI: 10.7270/Q29G5KGF
The Regents of the University of California US Patent					More data for this Ligand-Target Pair
Prokineticin receptor 1 (PRK1) (Cricetulus griseus (Chinese hamster))	BDBM121202 (US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethyla...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	7.18	-11.5	n/a	n/a	n/a	n/a	n/a	n/a	37
The Regents of the University of California US Patent					Assay Description An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...				US Patent US8722896 (2014) BindingDB Entry DOI: 10.7270/Q29G5KGF
The Regents of the University of California US Patent					More data for this Ligand-Target Pair
Prokineticin receptor 1 (PRK1) (Cricetulus griseus (Chinese hamster))	BDBM121202 (US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethyla...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	10.7	-11.3	n/a	n/a	n/a	n/a	n/a	n/a	37
The Regents of the University of California US Patent					Assay Description An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...				US Patent US8722896 (2014) BindingDB Entry DOI: 10.7270/Q29G5KGF
The Regents of the University of California US Patent					More data for this Ligand-Target Pair
Prokineticin receptor 1 (PRK1) (Cricetulus griseus (Chinese hamster))	BDBM121202 (US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethyla...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	11.4	-11.3	n/a	n/a	n/a	n/a	n/a	n/a	37
The Regents of the University of California US Patent					Assay Description An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...				US Patent US8722896 (2014) BindingDB Entry DOI: 10.7270/Q29G5KGF
The Regents of the University of California US Patent					More data for this Ligand-Target Pair
Prokineticin receptor 1 (PRK1) (Cricetulus griseus (Chinese hamster))	BDBM121202 (US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethyla...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	14.9	-11.1	n/a	n/a	n/a	n/a	n/a	n/a	37
The Regents of the University of California US Patent					Assay Description An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...				US Patent US8722896 (2014) BindingDB Entry DOI: 10.7270/Q29G5KGF
The Regents of the University of California US Patent					More data for this Ligand-Target Pair
Prokineticin receptor 1 (PRK1) (Cricetulus griseus (Chinese hamster))	BDBM121202 (US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethyla...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	18.1	-11.0	n/a	n/a	n/a	n/a	n/a	n/a	37
The Regents of the University of California US Patent					Assay Description An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...				US Patent US8722896 (2014) BindingDB Entry DOI: 10.7270/Q29G5KGF
The Regents of the University of California US Patent					More data for this Ligand-Target Pair
Prokineticin receptor 2 (PRK2) (Cricetulus griseus (Chinese hamster))	BDBM121202 (US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethyla...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	87.8	-10.0	n/a	n/a	n/a	n/a	n/a	n/a	37
The Regents of the University of California US Patent					Assay Description An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...				US Patent US8722896 (2014) BindingDB Entry DOI: 10.7270/Q29G5KGF
The Regents of the University of California US Patent					More data for this Ligand-Target Pair
Prokineticin receptor 1 (PRK1) (Cricetulus griseus (Chinese hamster))	BDBM121202 (US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethyla...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	240	-9.39	n/a	n/a	n/a	n/a	n/a	n/a	37
The Regents of the University of California US Patent					Assay Description An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...				US Patent US8722896 (2014) BindingDB Entry DOI: 10.7270/Q29G5KGF
The Regents of the University of California US Patent					More data for this Ligand-Target Pair