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TargetProkineticin receptor 1
LigandBDBM121202
Substrate/Competitorn/a
Meas. Tech.Calcium Mobilization Assay
Temperature310.15±n/a K
Ki 4.08±n/a nM
Commentsextracted
Citation Zhou, QLi, JHuang, Q Prokineticin receptor antagonists and uses thereof US Patent US8722896 Publication Date 5/13/2014
More Info.:Get all data from this article,  Assay Method
 
Prokineticin receptor 1
Name:Prokineticin receptor 1
Synonyms:Prokineticin receptor 1 (PRK1)
Type:Enzyme
Mol. Mass.:44908.29
Organism:Cricetulus griseus (Chinese hamster)
Description:G3HIE5
Residue:399
Sequence:
MPPPAWMEPTVGALGENTTDTSTSFLSLVNARGAQAASFPFTLSYGDYDTALGEEEDVTK
SWTFFAARIVIGMALVAIMLVCGVGNFIFITTLARYKKLRNLTNLLIANLAISDFLVAIV
CCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRM
KCQTAAGLIFLVWSVSILIAIPAAYFTTETVLVIVESQEKIFCGQIWPVDQQVYYRSYFL
LVFGLEFVGPVVAMTLCYARVSRELWFKAVPGFQTEQIRRRLRCRRRTVLGLVCVLSAYV
LCWAPFYGFTIVRDFFPSVFVKEKHYLTAFYVVECIAMSNSMINTLCFVSVRNNTSKYLK
RILRLQWRASPSGSKASADLDLRTTGMPATEEVDCIGLK
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  Blast E-value cutoff:
BDBM121202
n/a
NameBDBM121202
Synonyms:US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide | US8722896, (+/-)-2-Methyl-3-(indol-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide | US8722896, (-)-(2R)-2-Methyl-3-(indol-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
TypeSmall organic molecule
Emp. Form.C27H34ClN3O3
Mol. Mass.484.03
SMILESCC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc2[nH]ccc12
Structure
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