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BDBM12148 4-(N-(2-methylphenyl)sulfonylaminocarbonyl-hydrazinocarbonyl)-benzenesulfonamide::N-({[(2-methylbenzene)sulfonyl]carbamoyl}amino)-4-sulfamoylbenzamide::sulfonyl urea 4b

SMILES: Cc1ccccc1S(=O)(=O)NC(=O)NNC(=O)c1ccc(cc1)S(N)(=O)=O

InChI Key: InChIKey=HAQVUCZGHWJLBX-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 12148   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM12148
PNG
(4-(N-(2-methylphenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES Cc1ccccc1S(=O)(=O)NC(=O)NNC(=O)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C15H16N4O6S2/c1-10-4-2-3-5-13(10)27(24,25)19-15(21)18-17-14(20)11-6-8-12(9-7-11)26(16,22)23/h2-9H,1H3,(H,17,20)(H2,16,22,23)(H2,18,19,21)
PDB
MMDB

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KEGG

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PC cid
PC sid
UniChem

Similars

Article
PubMed
32n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM12148
PNG
(4-(N-(2-methylphenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES Cc1ccccc1S(=O)(=O)NC(=O)NNC(=O)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C15H16N4O6S2/c1-10-4-2-3-5-13(10)27(24,25)19-15(21)18-17-14(20)11-6-8-12(9-7-11)26(16,22)23/h2-9H,1H3,(H,17,20)(H2,16,22,23)(H2,18,19,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
54n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM12148
PNG
(4-(N-(2-methylphenyl)sulfonylaminocarbonyl-hydrazi...)
Show SMILES Cc1ccccc1S(=O)(=O)NC(=O)NNC(=O)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C15H16N4O6S2/c1-10-4-2-3-5-13(10)27(24,25)19-15(21)18-17-14(20)11-6-8-12(9-7-11)26(16,22)23/h2-9H,1H3,(H,17,20)(H2,16,22,23)(H2,18,19,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
800n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


J Med Chem 48: 2121-5 (2005)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q25X275C
More data for this
Ligand-Target Pair