BDBM124165 US8754075, 36

SMILES: C[C@@]1(N=C(N)OC[C@H]1F)c1cc(NC(=O)c2ncc(cc2Cl)C(F)(F)F)ccc1F

InChI Key: InChIKey=PUZPTNAELKFHSA-CXAGYDPISA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 124165   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 2 (Homo sapiens (Human))	BDBM124165 (US8754075, 36) Show SMILES C[C@@]1(N=C(N)OC[C@H]1F)c1cc(NC(=O)c2ncc(cc2Cl)C(F)(F)F)ccc1F |r,t:2| Show InChI InChI=1S/C18H14ClF5N4O2/c1-17(13(21)7-30-16(25)28-17)10-5-9(2-3-12(10)20)27-15(29)14-11(19)4-8(6-26-14)18(22,23)24/h2-6,13H,7H2,1H3,(H2,25,28)(H,27,29)/t13-,17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.03E+3	n/a	n/a	n/a	n/a	n/a	37
Hoffmann-La Roche Inc. US Patent					Assay Description The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...				US Patent US8754075 (2014) BindingDB Entry DOI: 10.7270/Q2FX784Q
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM124165 (US8754075, 36) Show SMILES C[C@@]1(N=C(N)OC[C@H]1F)c1cc(NC(=O)c2ncc(cc2Cl)C(F)(F)F)ccc1F |r,t:2| Show InChI InChI=1S/C18H14ClF5N4O2/c1-17(13(21)7-30-16(25)28-17)10-5-9(2-3-12(10)20)27-15(29)14-11(19)4-8(6-26-14)18(22,23)24/h2-6,13H,7H2,1H3,(H2,25,28)(H,27,29)/t13-,17-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	37
Hoffmann-La Roche Inc. US Patent					Assay Description The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...				US Patent US8754075 (2014) BindingDB Entry DOI: 10.7270/Q2FX784Q
					More data for this Ligand-Target Pair