BDBM124460 US8759532, 126

SMILES: FC1(CCOCC1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1

InChI Key: InChIKey=KAJOMQCXJLDKDV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124460   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM124460 (US8759532, 126) Show SMILES FC1(CCOCC1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 Show InChI InChI=1S/C24H20FN3O3/c25-24(11-14-30-15-12-24)18-4-3-13-26-23(18)31-17-9-7-16(8-10-17)21(29)22-27-19-5-1-2-6-20(19)28-22/h1-10,13H,11-12,14-15H2,(H,27,28)	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.311	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...				US Patent US8759532 (2014) BindingDB Entry DOI: 10.7270/Q25D8QHR
					More data for this Ligand-Target Pair