BDBM124540 US8759532, 218

SMILES: OC[C@H]1CC[C@H](C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1

InChI Key: InChIKey=PBAYSSFAKIJKMQ-FUHWJXTLSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124540   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM124540 (US8759532, 218) Show SMILES OC[C@H]1CC[C@H](C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |r| Show InChI InChI=1S/C25H23N3O3/c29-15-16-7-8-18(14-16)20-4-3-13-26-25(20)31-19-11-9-17(10-12-19)23(30)24-27-21-5-1-2-6-22(21)28-24/h1-6,9-13,16,18,29H,7-8,14-15H2,(H,27,28)/t16-,18+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.312	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...				US Patent US8759532 (2014) BindingDB Entry DOI: 10.7270/Q25D8QHR
					More data for this Ligand-Target Pair